反应详情

To an ice cooled solution of 3.69 g of 4-amino-3,3-dimethyl-1-[1-(R)-phenylethyl]-pyrrolidine in 40 ml of anhydrous tetrahydrofuran there was added 4.92 g of 2-(tert-butoxycarbonylamino)-2-phenylacetonitrile and the mixture was stirred at room temperature for 1 hr. Solvent was removed under reduced pressure, and to the residue there was added ethyl acetate. The mixture was washed with a 1N sodium hydroxide aqueous solution three times and then dried. Solvent was then removed under reduced pressure. The residue was purified through column chromatography using 200 g of silica gel in a column with chloroform as the eluant containing from 1% to 5% methanol to yield 4.32 g of the titled compound.

1. customSolvent was removed under reduced pressure
2. additionto the residue there was added ethyl acetate
3. washThe mixture was washed with a 1N sodium hydroxide aqueous solution three times
4. customdried
5. customSolvent was then removed under reduced pressure
6. customThe residue was purified through column chromatography
7. additioncontaining from 1% to 5% methanol