Hydrochloric Acid → HCID 18349789, compound

HRID 378616Notes

Reaction equation

HRID 378616 reaction equation
[ClH:1].Cl.[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([S:10][CH2:11][C:12]([NH:15][CH2:16][CH2:17][CH2:18][N:19]2[CH:23]=[CH:22][N:21]=[CH:20]2)([CH3:14])[CH3:13])=[CH:6][CH:5]=1.I([O-])(=O)(=O)=[O:25].[Na+].Cl>CO.CCOCC>[ClH:3].[ClH:1].[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([S:10]([CH2:11][C:12]([NH:15][CH2:16][CH2:17][CH2:18][N:19]2[CH:23]=[CH:22][N:21]=[CH:20]2)([CH3:13])[CH3:14])=[O:25])=[CH:6][CH:5]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 18349615HCID 18349615, compoundHCID 23667635Sodium periodate

Product 1

HCID 18349789HCID 18349789, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 3283Diethyl EtherSolvent

Procedure

N-[2-(4-Chlorophenylthio)-1,1-dimethylethyl]-3-(imidazol-1-yl)propylamine dihydrochloride (1.0 g) was added in one portion to a stirred solution of sodium periodate (0.54 g) in aqueous methanol (15 ml of a 1:1 mixture) at 5-10° C. The mixture was stirred at ambient temperature for 24 hours and then evaporated to dryness. 5M Sodium hydroxide solution was added to the residue and the mixture extracted with dichloromethane to give an oil which was dissolved in ether containing a small amount of absolute alcohol and treated with ethereal hydrogen chloride. The mixture was filtered to give N-[2-(4-chlorophenylsulphinyl)-1,1-dimethylethyl]-3-(imidazol-1-yl)propylamine dihydrochloride, m.p. 208-211° C.

Workup

  1. customevaporated to dryness
  2. addition5M Sodium hydroxide solution was added to the residue
  3. extractionthe mixture extracted with dichloromethane
  4. customto give an oil which
  5. filtrationThe mixture was filtered

Sources & evidence

ORD record
ord-921f9c32e64346aa904f876ef141a3ea
Source dataset
uspto-grants-2000_02
Patent number
US06031109

Reaction notes

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