反应详情

温度

220 °C

A mixture of phenol (33.2 g) and 2,4,4-trimethyloxazoline (18.1 g) was heated in a stirred pressure vessel at 220° C. for 48 hours. The oil obtained on cooling was dissolved in ethyl acetate, washed with 5M sodium hydroxide solution, water, brine, then dried and evaporated to give an oil which was distilled under high vacuum to give N-(1,1-dimethyl-2-phenoxyethyl)acetamide, b.p. 115-122° C. at 0.67 mbar.

1. customThe oil obtained
2. temperatureon cooling
3. washwashed with 5M sodium hydroxide solution, water, brine
4. customdried
5. customevaporated
6. customto give an oil which
7. distillationwas distilled under high vacuum