2-Amino-2-methyl-1-propanol → 2-[3-(Imidazol-1-yl)propylamino]-2-methyl-1-propanol

HRID 378652Notes

Reaction equation

HRID 378652 reaction equation
C(O[CH:4](OCC)[CH2:5][CH2:6][N:7]1[CH:11]=[CH:10][N:9]=[CH:8]1)C.[NH2:15][C:16]([CH3:20])([CH3:19])[CH2:17][OH:18]>C(#N)C>[N:7]1([CH2:6][CH2:5][CH2:4][NH:15][C:16]([CH3:20])([CH3:19])[CH2:17][OH:18])[CH:11]=[CH:10][N:9]=[CH:8]1

Participants

4

Reactant 2

HCID 118072-Amino-2-methyl-1-propanolHCID 183496641-(3,3-diethoxypropyl)-1H-imidazole

Product 1

HCID 183497652-[3-(Imidazol-1-yl)propylamino]-2-methyl-1-propanol

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

3-(Imidazol-1-yl)propionaldehyde diethyl acetal (8.1 g) was converted into the free aldehyde, as described in Example 24, and then added to a mixture of 2-amino-2-methylpropanol (1.83 g) in acetonitrile (40 ml) and 4A molecular sieves (6.0 g). The mixture was reacted following the procedure of Example 24 to give 2-[3-(imidazol-1-yl)propylamino]-2-methyl-1-propanol, m.p. 81-85° C.

Workup

  1. customThe mixture was reacted

Sources & evidence

ORD record
ord-94c8b9cb4be44762994c88c1f701af55
Source dataset
uspto-grants-2000_02
Patent number
US06031109

Reaction notes

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