Carbon Dioxide → 8-(4-Benzyloxy-phenyl)-10-[(2-methoxy-ethyl)-phenyl-carbamoyl]-7-oxo-7H-thieno[2,3-a]quinolizine-2-carboxylic acid

HRID 378673Notes

Reaction equation

HRID 378673 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][N:5]([C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)[C:6]([C:8]1[CH:9]=[C:10]([C:22]2[CH:27]=[CH:26][C:25]([O:28][CH2:29][C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)=[CH:24][CH:23]=2)[C:11](=[O:21])[N:12]2[C:17]=1[C:16]1[S:18][CH:19]=[CH:20][C:15]=1[CH:14]=[CH:13]2)=[O:7].[C:42](=[O:44])=[O:43]>>[CH2:29]([O:28][C:25]1[CH:26]=[CH:27][C:22]([C:10]2[C:11](=[O:21])[N:12]3[C:17](=[C:8]([C:6](=[O:7])[N:5]([CH2:4][CH2:3][O:2][CH3:1])[C:36]4[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=4)[CH:9]=2)[C:16]2[S:18][C:19]([C:42]([OH:44])=[O:43])=[CH:20][C:15]=2[CH:14]=[CH:13]3)=[CH:23][CH:24]=1)[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1

Participants

3

Reactant 2

HCID 280Carbon DioxideHCID 566362588-(4-Benzyloxy-phenyl)-7-oxo-7H-thieno[2,3-a]quinolizine-10-carboxylic acid (2-methoxy-ethyl)-phenyl-amide

Product 1

HCID 193536688-(4-Benzyloxy-phenyl)-10-[(2-methoxy-ethyl)-phenyl-carbamoyl]-7-oxo-7H-thieno[2,3-a]quinolizine-2-carboxylic acid

Procedure

By lithiation of 8-(4-benzyloxy-phenyl)-7-oxo-7H-thieno[2,3-a]quinolizine-10-carboxylic acid (2-methoxy-ethyl)-phenyl-amide and reaction with carbon dioxide.

Sources & evidence

ORD record
ord-146f206411834f2080006b52e9180cb1
Source dataset
uspto-grants-2000_02
Patent number
US06030984

Reaction notes

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