Triethylamine → HCID 56612952, compound

HRID 378678Notes

Reaction equation

HRID 378678 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[C:16](=[O:31])[N:17]3[C:22](=[C:23]([C:25](O)=[O:26])[CH:24]=2)[C:21]2[S:28][CH:29]=[CH:30][C:20]=2[CH:19]=[CH:18]3)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O=S(Cl)Cl.C(N(CC)CC)C.[CH2:43]([O:45][CH2:46][CH2:47][NH:48][C:49]1[N:54]=[CH:53][CH:52]=[CH:51][N:50]=1)C>C1(C)C=CC=CC=1.ClCCl>[CH3:43][O:45][CH2:46][CH2:47][N:48]([C:49]1[N:50]=[CH:51][CH:52]=[CH:53][N:54]=1)[C:25]([C:23]1[CH:24]=[C:15]([C:12]2[CH:13]=[CH:14][C:9]([O:8][CH2:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)=[CH:10][CH:11]=2)[C:16](=[O:31])[N:17]2[C:22]=1[C:21]1[S:28][CH:29]=[CH:30][C:20]=1[CH:19]=[CH:18]2)=[O:26]

Participants

7

Reactant 4

HCID 8471TriethylamineHCID 24386Thionyl ChlorideHCID 19353603HCID 19353603, compoundHCID 193536298-[p-(benzyloxy)phenyl]-7-oxo-7H-thieno[2,3-a]quinolizine-10-carboxylic acid

Product 1

HCID 56612952HCID 56612952, compound

Reagents, catalysts & solvents 2

HCID 1140TolueneSolventHCID 6344DichloromethaneSolvent

Procedure

From 8-[p-(benzyloxy)phenyl]-7-oxo-7H-thieno[2,3-a]quinolizine-10-carboxylic acid with SOCl2 in toluene. Then treatment with triethylamine and (2-ethoxy-ethyl)-pyrimidin-2-yl-amine in dichloromethane.

Sources & evidence

ORD record
ord-24647ae2faf946d09211afde2261c93c
Source dataset
uspto-grants-2000_02
Patent number
US06030984

Reaction notes

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