Phosphorus trichloride → HCID 21696607, compound

HRID 378782Notes

Reaction equation

HRID 378782 reaction equation
[Cl:1][C:2]1[C:3]([C:13]([O:15][CH3:16])=[O:14])=[N:4][CH:5]=[C:6]([O:11][CH3:12])[C:7]=1[N+:8]([O-:10])=[O:9].P(Cl)(Cl)[Cl:18]>C(Cl)(Cl)Cl>[Cl:1][C:2]1[C:3]([C:13]([O:15][CH3:16])=[O:14])=[N:4][C:5]([Cl:18])=[C:6]([O:11][CH3:12])[C:7]=1[N+:8]([O-:10])=[O:9]

Participants

4

Reactant 2

HCID 24387Phosphorus trichlorideHCID 21696599HCID 21696599, compound

Product 1

HCID 21696607HCID 21696607, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To methyl 3-chloro-5-methoxy-4-nitro-pyridine-2-carboxylate, N-oxide (0.300 g, 1.12 mmol) in 5 mL of chloroform was added PCl3 (0.664 mL, 7.62 mmol). The reaction mixture was heated to reflux for 8 hr and then concentrated to dryness in vacuo to give 300 mg of a white solid.

Workup

  1. temperatureThe reaction mixture was heated
  2. temperatureto reflux for 8 hr
  3. concentrationconcentrated to dryness in vacuo

Sources & evidence

ORD record
ord-120f3afc236e422bb9992147bd079efa
Source dataset
uspto-grants-2001_10
Patent number
US06297197B1

Reaction notes

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