反应详情

To methyl-4-amino-6-bromo-5-chloro-3-methoxypyridine-2-carboxylate (0.300 g, 1.02 mmol) in 10 mL of methanol was added 1 N NaOH (1.10 mL, 1.10 mmol). The reaction mixture was stirred at room temperature for 4 hr and was then concentrated to dryness in vacuo. The resulting aqueous layer was acidified with concentrated HCl. The white solid was collected by filtration and was rinsed with H2O. The solid was dried at 50° C. under vacuum to give 0.230 g of a white fluffy solid; mp 154-156° C.

1. concentrationwas then concentrated to dryness in vacuo
2. filtrationThe white solid was collected by filtration
3. washwas rinsed with H2O
4. customThe solid was dried at 50° C. under vacuum