Sodium Hydroxide → 4-Amino-6-bromo-5-chloro-3-methoxypyridine-2-carboxylic acid

Participants

Reaction Steps

To methyl-4-amino-6-bromo-5-chloro-3-methoxypyridine-2-carboxylate (0.300 g, 1.02 mmol) in 10 mL of methanol was added 1 N NaOH (1.10 mL, 1.10 mmol). The reaction mixture was stirred at room temperature for 4 hr and was then concentrated to dryness in vacuo. The resulting aqueous layer was acidified with concentrated HCl. The white solid was collected by filtration and was rinsed with H2O. The solid was dried at 50° C. under vacuum to give 0.230 g of a white fluffy solid; mp 154-156° C.

Provenance & Evidence