Hydrazine hydrate (1:1) → 4-Methyl-1,3-thiazole-2-carbohydrazide

HRID 378838Notes

Reaction equation

HRID 378838 reaction equation
[CH3:1][C:2]1[N:3]=[C:4]([C:7]([O:9]C)=O)[S:5][CH:6]=1.O.[NH2:12][NH2:13]>CO>[CH3:1][C:2]1[N:3]=[C:4]([C:7]([NH:12][NH2:13])=[O:9])[S:5][CH:6]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 11435075Methyl 4-methylthiazole-2-carboxylate

Product 1

HCID 112289374-Methyl-1,3-thiazole-2-carbohydrazide

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of methyl 4-methyl-2-thiazole carboxylate (step a, 2.1 g) in methanol (20 ml) was added hydrazine hydrate (3.2 ml) dropwise over 30 mins. The reaction mixture was stirred for 1.5 hours and the precipitate filtered off to yield the title compound as a white solid (1.6 g). 1H NMR (250 MHz, DMSO) δ 2.64 (3H, s), 4.82 (2H, bs), 7.79 (1H, s), 10.25 (1H, bs).

Workup

  1. filtrationthe precipitate filtered off

Sources & evidence

ORD record
ord-b771700b949f4db7b27895c73649a0e0
Source dataset
uspto-grants-2001_10
Patent number
US06297235B1

Reaction notes

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