4-Cyanobenzenesulfonyl chloride → HCID 8469453, compound

HRID 378849Notes

Reaction equation

HRID 378849 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([S:9](Cl)(=[O:11])=[O:10])=[CH:5][CH:4]=1)#[N:2].[O:13]1[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][NH2:21])[CH2:15][CH2:14]1>CC(C)=O>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([S:9]([NH:21][CH2:20][CH2:19][N:16]2[CH2:17][CH2:18][O:13][CH2:14][CH2:15]2)(=[O:11])=[O:10])=[CH:5][CH:4]=1)#[N:2]

Participants

4

Reactant 2

HCID 394974-Cyanobenzenesulfonyl chlorideHCID 4082852-Morpholinoethylamine

Product 1

HCID 8469453HCID 8469453, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent2×

Procedure

A mixture of 4-cyanobenzene sulphonyl chloride (5.15 g) in acetone (70 ml) was stirred at ambient temperature and then a solution of 2-morpholinoethylamine (6.7 ml) in acetone (15 ml) was added dropwise with stirring. The mixture was stirred at ambient temperature for 2 hours and then the acetone was removed by evaporation and the residue was eluted through a silica pad using ethyl acetate to give 4-cyano-N-2-morpholinoethyl-benzenesulphonamide.

Workup

  1. stirringwith stirring
  2. stirringThe mixture was stirred at ambient temperature for 2 hours
  3. customthe acetone was removed by evaporation
  4. washthe residue was eluted through a silica pad

Sources & evidence

ORD record
ord-47524cdf879c4f1eb786ed1a63d55d17
Source dataset
uspto-grants-2001_10
Patent number
US06297238B1

Reaction notes

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