Benzaldehyde → HCID 22558189, compound

HRID 378865Notes

Reaction equation

HRID 378865 reaction equation
[NH2:1][C:2]1[C:17]([Cl:18])=[CH:16][C:5]2[N:6]=[C:7]([N:9]3[CH2:14][CH2:13][N:12]([CH3:15])[CH2:11][CH2:10]3)[O:8][C:4]=2[CH:3]=1.[CH:19](=O)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>C1(C)C=CC=CC=1>[CH:19](=[N:1][C:2]1[C:17]([Cl:18])=[CH:16][C:5]2[N:6]=[C:7]([N:9]3[CH2:10][CH2:11][N:12]([CH3:15])[CH2:13][CH2:14]3)[O:8][C:4]=2[CH:3]=1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

4

Reactant 2

HCID 240BenzaldehydeHCID 12016519HCID 12016519, compound

Product 1

HCID 22558189HCID 22558189, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A 30 mg portion of 6-amino-5-chloro-2-(4-methyl-1-piperazinyl)benzoxazole was dissolved in 20 ml of anhydrous toluene, and the solution was mixed with 1 ml of benzaldehyde and heated under reflux for 6 hours. The solvent was concentrated under a reduced pressure, the residual oily matter was mixed with hexane and then the thus formed precipitate was collected by filtration to obtain the title compound (24 mg) in white color.

Workup

  1. temperatureheated
  2. temperatureunder reflux for 6 hours
  3. concentrationThe solvent was concentrated under a reduced pressure
  4. additionthe residual oily matter was mixed with hexane
  5. filtrationthe thus formed precipitate was collected by filtration

Sources & evidence

ORD record
ord-2b0ab377469d4c8a9c3c620d7240b83d
Source dataset
uspto-grants-2001_10
Patent number
US06297246B1

Reaction notes

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