反应详情

A 30 mg portion of 6-amino-5-chloro-2-(4-methyl-1-piperazinyl)benzoxazole was dissolved in 20 ml of anhydrous toluene, and the solution was mixed with 1 ml of benzaldehyde and heated under reflux for 6 hours. The solvent was concentrated under a reduced pressure, the residual oily matter was mixed with hexane and then the thus formed precipitate was collected by filtration to obtain the title compound (24 mg) in white color.

1. temperatureheated
2. temperatureunder reflux for 6 hours
3. concentrationThe solvent was concentrated under a reduced pressure
4. additionthe residual oily matter was mixed with hexane
5. filtrationthe thus formed precipitate was collected by filtration