Benzophenone [6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]hydrazone → 4-Hydrazino-6-(4-methylpiperazin-1-yl)pyrimidine

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Reaction Steps

300 mg (808 μmol) of the compound from Example 5A in 15 ml conc. hydrochloric acid are heated at 65° C. for 4 h. After cooling, the reaction mixture is washed with dichloromethane and the aqueous phase is concentrated. This gives 162 mg of the crude product as the hydrochloride. This is stirred with polymer-bound tris-(2-aminoethyl)amine in dichloromethane at RT. After filtration, the filtrate is concentrated and the residue is dried under high vacuum.

Provenance & Evidence