反应详情

300 mg (808 μmol) of the compound from Example 5A in 15 ml conc. hydrochloric acid are heated at 65° C. for 4 h. After cooling, the reaction mixture is washed with dichloromethane and the aqueous phase is concentrated. This gives 162 mg of the crude product as the hydrochloride. This is stirred with polymer-bound tris-(2-aminoethyl)amine in dichloromethane at RT. After filtration, the filtrate is concentrated and the residue is dried under high vacuum.

1. temperatureAfter cooling
2. washthe reaction mixture is washed with dichloromethane
3. concentrationthe aqueous phase is concentrated
4. filtrationAfter filtration
5. concentrationthe filtrate is concentrated
6. customthe residue is dried under high vacuum