HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → 4-Chloro-6-piperidin-1-ylpyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 4,6-Dichloropyrimidine | HCID 70943 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-Chloro-6-piperidin-1-ylpyrimidine | HCID 597870 | — |
Reaction Conditions
| Temperature | 115 °C |
|---|
Reaction Steps
A mixture of 10.0 g (67.1 mmol) of 4,6-dichloropyrimidine and 5.7 g (67.1 mmol) of piperidine in 100 ml of water is stirred at a bath temperature of 115° C. for 16 h. After cooling to RT, the precipitate is filtered off, washed with water and dried under reduced pressure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08524699B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-adb50cf1fd4b407c85e6ba3fbe2a66ab |
| Source note | uspto-grants-2013_09 |