Piperidine → 4-Chloro-6-piperidin-1-ylpyrimidine

HRID 37889Notes

Reaction equation

HRID 37889 reaction equation
Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[CH:4][N:3]=1.[NH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1>O>[Cl:8][C:6]1[CH:7]=[C:2]([N:9]2[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)[N:3]=[CH:4][N:5]=1

Participants

4

Reactant 2

HCID 8082PiperidineHCID 709434,6-Dichloropyrimidine

Product 1

HCID 5978704-Chloro-6-piperidin-1-ylpyrimidine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
115 °C

Procedure

A mixture of 10.0 g (67.1 mmol) of 4,6-dichloropyrimidine and 5.7 g (67.1 mmol) of piperidine in 100 ml of water is stirred at a bath temperature of 115° C. for 16 h. After cooling to RT, the precipitate is filtered off, washed with water and dried under reduced pressure.

Workup

  1. temperatureAfter cooling to RT
  2. filtrationthe precipitate is filtered off
  3. washwashed with water
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-adb50cf1fd4b407c85e6ba3fbe2a66ab
Source dataset
uspto-grants-2013_09
Patent number
US08524699B2

Reaction notes

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