Oxalyl chloride → 4-Bromo-2-methylbenzoyl chloride

HRID 378894Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 378894
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](O)=[O:7])=[C:4]([CH3:11])[CH:3]=1.C(Cl)(=O)C([Cl:15])=O>ClCCl>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([Cl:15])=[O:7])=[C:4]([CH3:11])[CH:3]=1

Komponenten

4

Edukt 2

HCID 65578Oxalyl chlorideHCID 995704-Bromo-2-methylbenzoic acid

Produkt 1

HCID 128464834-Bromo-2-methylbenzoyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneKatalysator

Versuchsvorschrift

A suspension of 4bromo-2-methylbenzoic acid (4.9 g, 22.8 mmol) in dichioromethane containing a few drops of N,N-dimethylformamde was treated dropwise under nitrogen with oxalyl chloride (2.4 mL, 27.5 mol). After gas evolution subsided, the reaction mixture was refluxed for an additional 15 minutes and then evaporated to dryness in vacuo to provide the crude 4-bromo-2-methylbenzoyl chloride.

Aufarbeitung

  1. temperaturethe reaction mixture was refluxed for an additional 15 minutes
  2. customevaporated to dryness in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-b5ef46d355a645e1ae379e14e4216879
Quelldatensatz
uspto-grants-2001_10
Patentnummer
US06297234B1

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