反应详情

Compound No. 45. (CNI-4594) A mixture of aniline (0.93 g) and 2-amino-4-chloro-6-methylpyrimidine (1.44 g) in 36 mL water was treated with 0.84 mL conc HCl and heated at reflux for 1 hr. Addition of 20 mL 1N KOH gave a light buff solid, which was filtered out, dried, and recrystallized from ethyl acetate/2-methoxyethanol and ethyl acetate/hexane to give 0.69 g 4-phenylamino-2-amino-6-methylpyrimidine, mp 179-180° C.

1. temperatureheated
2. temperatureat reflux for 1 hr
3. customgave a light buff solid, which
4. filtrationwas filtered out
5. customdried
6. customrecrystallized from ethyl acetate/2-methoxyethanol and ethyl acetate/hexane