HCID 178514071, compound → HCID 178514069, compound

HRID 378958Notes

Reaction equation

HRID 378958 reaction equation
[F:1][C:2]([F:28])([F:27])[C:3]1[CH:4]=[C:5]([N:9]([C:13]2[CH:18]=[CH:17][C:16]([N+:19]([O-])=O)=[CH:15][C:14]=2[C:22]2[NH:26][N:25]=[N:24][N:23]=2)[C:10]([NH2:12])=[O:11])[CH:6]=[CH:7][CH:8]=1>C(O)C.[Pd]>[F:28][C:2]([F:1])([F:27])[C:3]1[CH:4]=[C:5]([N:9]([C:13]2[CH:18]=[CH:17][C:16]([NH2:19])=[CH:15][C:14]=2[C:22]2[NH:26][N:25]=[N:24][N:23]=2)[C:10]([NH2:12])=[O:11])[CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 1

HCID 178514071HCID 178514071, compound

Product 1

HCID 178514069HCID 178514069, compoundYield 103.2%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 3-trifluoromethylphenyl-4-nitro-2-(5-tetrazolyl)phenyl urea (0.8 g, 2.0 mmol) in 96% ethanol was hydrogenated over 5% palladium on charcoal for 3 hours at room temperature. The reaction mixture was filtered through a pad of celite and the solvent evaporated off to give 0.75 g of the desired product. M.p. 175-180° C.

Workup

  1. filtrationThe reaction mixture was filtered through a pad of celite
  2. customthe solvent evaporated off

Sources & evidence

ORD record
ord-2b40284544454a90bdd10c8cc3b141e6
Source dataset
uspto-grants-2001_10
Patent number
US06297261B1

Reaction notes

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