Hydrochloric Acid → HCID 178514068, compound

HRID 378963Notes

Reaction equation

HRID 378963 reaction equation
[F:1][C:2]([F:36])([F:35])[C:3]1[CH:4]=[C:5]([N:9]([C:13]2[CH:18]=[CH:17][C:16]([C:19]3[CH:24]=[CH:23][C:22]([C:25]([O:27]CC)=[O:26])=[CH:21][CH:20]=3)=[CH:15][C:14]=2[C:30]2[NH:34][N:33]=[N:32][N:31]=2)[C:10]([NH2:12])=[O:11])[CH:6]=[CH:7][CH:8]=1.[OH-].[Na+].Cl>C(O)C>[F:36][C:2]([F:1])([F:35])[C:3]1[CH:4]=[C:5]([N:9]([C:13]2[CH:18]=[CH:17][C:16]([C:19]3[CH:20]=[CH:21][C:22]([C:25]([OH:27])=[O:26])=[CH:23][CH:24]=3)=[CH:15][C:14]=2[C:30]2[NH:34][N:33]=[N:32][N:31]=2)[C:10]([NH2:12])=[O:11])[CH:6]=[CH:7][CH:8]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178468740HCID 178468740, compound

Product 1

HCID 178514068HCID 178514068, compoundYield 90.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a suspension of 3-trifluoromethylphenyl-4-(4-ethoxycarbonylphenyl) -2-(5-tetrazolyl)phenyl urea (4.5 g, 9 mmol) in 96% ethanol was added sodium hydroxide (4 N, 25 mL). The reaction was heated to reflux for 30 min, then cooled to room temperature and acidified with hydrochloric acid. The precipitate was filtered off to give 3.8 g of the desired material. M.p. 300° C. (dec.).

Workup

  1. temperatureThe reaction was heated
  2. temperatureto reflux for 30 min
  3. filtrationThe precipitate was filtered off

Sources & evidence

ORD record
ord-2472319b60bf4b51b0acf256c5193e61
Source dataset
uspto-grants-2001_10
Patent number
US06297261B1

Reaction notes

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