Ethanol → HCID 21697690, compound

HRID 378987Notes

Reaction equation

HRID 378987 reaction equation
[O:1]=[S:2]1(=[O:16])[CH:6]([F:7])[C:5]2[C:8]([Cl:15])=[CH:9][CH:10]=[C:11]([N+:12]([O-])=O)[C:4]=2[NH:3]1.[Sn](Cl)Cl.[CH2:20](O)C>>[O:1]=[S:2]1(=[O:16])[C:6]([F:7])([CH3:20])[C:5]2[C:8]([Cl:15])=[CH:9][CH:10]=[C:11]([NH2:12])[C:4]=2[NH:3]1

Participants

4

Reactant 3

HCID 702EthanolHCID 24479Stannous ChlorideHCID 21697693HCID 21697693, compound

Product 1

HCID 21697690HCID 21697690, compoundYield 47%

Procedure

To the solution of 1,3-dihydro-2,2-dioxo-4-chloro-3-fluoro-7-nitro-2,1-benzisothiazole (100 mg, 0.4 mmol) in ethanol (10 ml), Tin (II) chloride (443 mg, 2.0 mmol) was added. The reaction mixture was stirred at room temperature for about 16 hours. Then all solvent was evaporated. Chromatography of the residue on silica gel (50% Ethyl acetate/Hexane) gave desired product (43 mg, 47%). EI-MS m/z 237.2 (M+).

Workup

  1. customThen all solvent was evaporated

Sources & evidence

ORD record
ord-b5333b8af1b3464ca4cb84fe878cbadc
Source dataset
uspto-grants-2001_10
Patent number
US06297265B2

Reaction notes

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