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HRID378990

反应详情

EQUATION

反应方程式

HRID 378990 的结构方程式

REACTANTS

反应物

3
结构：CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F
HCID2733084

Methanaminium, N-[(1H-benzotriazol-1-yloxy)(dimethylamino)methylene]-N-methyl-, hexafluorophosphate(1-) (1:1)

C11H16F6N5OP

结构：CCOC(=O)COc1ccc(N)cc1.Cl
HCID21697723

Ethyl (4-aminophenoxy)acetate--hydrogen chloride (1/1)

C10H14ClNO3

结构：Cc1nc(NC(=N)N)sc1C(=O)O
HCID178433209

未命名化合物

PRODUCTS

生成物

1
结构：CCOC(=O)COc1ccc(NC(=O)c2sc(NC(=N)N)nc2C)cc1
HCID178473011

未命名化合物

收率 48.8%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

400 mg of 2-guanidino-4-methyl-thiazole-5-carboxylic acid, 463 mg of ethyl 4-amino-phenyloxyacetate hydrochloride, 6 ml of DMF, 0.67 ml of N-MM and 759 mg of HBTU are stirred at RT for 22 hrs. The working up and purification are effected as described in Example 1. Crystallization from acetonitrile (MeCN) gives 368 mg of ethyl {4-[(2-guanidino-4-methyl-thiazole-5-carbonyl)-amino]-phenoxy}-acetate, m.p. 223° C.;, MS: 378 (M+H)+.

WORKUP

后处理

  1. customThe working up and purification
  2. customCrystallization from acetonitrile (MeCN)