Hydrochloric Acid → HCID 178479414, compound

HRID 378995Notes

Reaction equation

HRID 378995 reaction equation
[NH:1]([C:5]1[S:6][CH:7]=[C:8]([C:10]([NH:12][C:13]2[CH:25]=[CH:24][C:16]([O:17][CH2:18][C:19]([O:21]CC)=[O:20])=[CH:15][CH:14]=2)=[O:11])[N:9]=1)[C:2]([NH2:4])=[NH:3].[ClH:26]>>[ClH:26].[NH:1]([C:5]1[S:6][CH:7]=[C:8]([C:10]([NH:12][C:13]2[CH:25]=[CH:24][C:16]([O:17][CH2:18][C:19]([OH:21])=[O:20])=[CH:15][CH:14]=2)=[O:11])[N:9]=1)[C:2]([NH2:4])=[NH:3]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 178473010HCID 178473010, compound

Product 1

HCID 178479414HCID 178479414, compound

Procedure

227 mg of ethyl {4-[(2-guanidino-thiazole-4-carbonyl)-amino]-phenoxy}-acetate are stirred for 3 days at RT in 25% hydrochloric acid. The precipitate is filtered off under suction, washed with water, triturated in methanol, filtered off under suction and dried. There are obtained 165 mg of [4-[(2-guanidino-thiazole-4-carbonyl)- amino]-phenoxy]-acetic acid hydrochloride (1:1); m.p. 278° C., MS: 336 (M+H)+.

Workup

  1. filtrationThe precipitate is filtered off under suction
  2. washwashed with water
  3. customtriturated in methanol
  4. filtrationfiltered off under suction
  5. customdried

Sources & evidence

ORD record
ord-787a38e20a47491382b91bb214c6525e
Source dataset
uspto-grants-2001_10
Patent number
US06297266B1

Reaction notes

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