Hydrochloric Acid → HCID 178479413, compound

HRID 378996Notes

Reaction equation

HRID 378996 reaction equation
[NH:1]([C:5]1[S:6][C:7]([C:10]([NH:12][C:13]2[CH:25]=[CH:24][C:16]([O:17][CH2:18][C:19]([O:21]CC)=[O:20])=[CH:15][CH:14]=2)=[O:11])=[CH:8][N:9]=1)[C:2]([NH2:4])=[NH:3].[ClH:26]>>[ClH:26].[NH:1]([C:5]1[S:6][C:7]([C:10]([NH:12][C:13]2[CH:25]=[CH:24][C:16]([O:17][CH2:18][C:19]([OH:21])=[O:20])=[CH:15][CH:14]=2)=[O:11])=[CH:8][N:9]=1)[C:2]([NH2:4])=[NH:3]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 178473009HCID 178473009, compound

Product 1

HCID 178479413HCID 178479413, compound

Procedure

239 mg of ethyl {4-[(2-guanidino-thiazole-5-carbonyl)-amino]-phenoxy}-acetate are stirred for 27 hrs. in 4.8 ml of 25% hydrochloric acid. The precipitate is filtered off under suction, washed with water and dried. There are obtained 222 mg of [4-[(2-guanidino-thiazole-5-carbonyl)-amino]-phenoxy]-acetic acid hydrochloride (1:1), m.p. 336° C., MS: 364 (M+H)+.

Workup

  1. filtrationThe precipitate is filtered off under suction
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-0ae7de55e16d40a294214ccf398de480
Source dataset
uspto-grants-2001_10
Patent number
US06297266B1

Reaction notes

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