反应详情

243 mg of ethyl (4-{[2-(3-benzyl-ureido)-thiazole-4-carbonyl]-amino}-phenoxy)-acetate are stirred in 4.3 ml of ethanol and 0.8 ml of 1N NaOH for 4.5 hrs. at RT. For the working up, the mixture is stirred into ethyl acetate/dilute hydrochloric acid, the organic phase is separated, washed with water and sodium chloride solution, dried over sodium sulphate dried and evaporated in a vacuum. Crystallization from ether gives 208 mg of [4-[[2-(3-benzyl-ureido)-thiazole-4-carbonyl]-amino]-phenoxy]-acetic acid, m.p. 208° C., MS: 427 (M+H)+.

1. customat RT
2. customthe organic phase is separated
3. washwashed with water and sodium chloride solution
4. dry with materialdried over sodium sulphate
5. customdried
6. customevaporated in a vacuum
7. customCrystallization from ether