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HRID379000

反应详情

EQUATION

反应方程式

HRID 379000 的结构方程式

REACTANTS

反应物

2
结构：CCOC(=O)/C=C/c1ccc(N)cc1
HCID736317

未命名化合物

结构：O=C(NCc1ccccc1)Nc1nc(C(=O)O)cs1
HCID18322865

未命名化合物

PRODUCTS

生成物

1
结构：CCOC(=O)/C=C/c1ccc(NC(=O)c2csc(NC(=O)NCc3ccccc3)n2)cc1
HCID86757464

未命名化合物

PROCEDURE

实验过程

2-(3-Benzyl-ureido)-thiazole-4-carboxylic acid is coupled with ethyl (E)-3-(4-amino-phenyl)-acrylate in analogy to Example 11 After chromatography on silica gel with methylene chloride-ethanol 98:2 and crystallization from ether there is obtained ethyl (E)-3-[4-[[2-(3-benzyl-ureido)-thiazole-4-carbonyl]-amino]-phenyl]-acrylate, m.p. 207° C., MS: 451 (M+H)+.

WORKUP

后处理

  1. customwith methylene chloride-ethanol 98:2 and crystallization from ether