2-Hydroxy-4-imidazol-1-ylmethyl-benzonitrile → 2-(Biphenyl-4-ylmethoxy)-4-imidazol-1-ylmethyl-benzonitrile

HRID 379026Notes

Reaction equation

HRID 379026 reaction equation
[OH:1][C:2]1[CH:9]=[C:8]([CH2:10][N:11]2[CH:15]=[CH:14][N:13]=[CH:12]2)[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[C:16]1([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:21]=[CH:20][C:19]([CH2:22]I)=[CH:18][CH:17]=1>>[C:16]1([C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=2)[CH:17]=[CH:18][C:19]([CH2:22][O:1][C:2]2[CH:9]=[C:8]([CH2:10][N:11]3[CH:15]=[CH:14][N:13]=[CH:12]3)[CH:7]=[CH:6][C:3]=2[C:4]#[N:5])=[CH:20][CH:21]=1

Participants

3

Reactant 2

HCID 216970282-Hydroxy-4-imidazol-1-ylmethyl-benzonitrileHCID 219099744-(Iodomethyl)biphenyl

Product 1

HCID 99510072-(Biphenyl-4-ylmethoxy)-4-imidazol-1-ylmethyl-benzonitrile

Procedure

Following the procedure described in Example 2, Step E but using 2-hydroxy-4-imidazol-1-ylmethyl-benzonitrile (as described in Step F) and biphenyl-4-ylmethyl iodide as starting materials, the title compound was obtained as a solid.

Sources & evidence

ORD record
ord-a8bc31dadcec409bb8d84f586d633be9
Source dataset
uspto-grants-2001_10
Patent number
US06297239B1

Reaction notes

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