反应详情

4-bromomethyl-2-hydroxy-benzonitrile (0.22 g, 1.05 mmol) and imidazole (0.36 g, 5.23 mmol) were dissolved in DMF (10 mL) with stirring at ambient temperature. After stirring for 18 h, the reaction mixture was concentrated in vacuo and purified by silica gel chromatography eluting with 2% CH3OH/CH2C12 to 5% CH3OH/CH2Cl2 to give the title compound.

1. stirringAfter stirring for 18 h
2. concentrationthe reaction mixture was concentrated in vacuo
3. custompurified by silica gel chromatography
4. washeluting with 2% CH3OH/CH2C12 to 5% CH3OH/CH2Cl2