HCID 21696955, compound → HCID 21696967, compound

HRID 379052Notes

Reaction equation

HRID 379052 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:10]2[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][CH:11]=2)[OH:9])=[CH:4][C:3]=1[F:17]>C(Cl)Cl.O=[Mn]=O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:10]2[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][CH:11]=2)=[O:9])=[CH:4][C:3]=1[F:17]

Participants

4

Reactant 1

HCID 21696955HCID 21696955, compound

Product 1

HCID 21696967HCID 21696967, compound

Reagents, catalysts & solvents 2

HCID 14801Manganese dioxideCatalystHCID 6344DichloromethaneSolvent

Procedure

(4-Bromo-3-fluoro-phenyl)-(4-chloro-phenyl)-methanol (2.26 g, 7.16 mmol) and MnO2 (6.22 g, 70.1 mmol) was stirred in CH2Cl2 (40 mL) for 40 hr. The solution was filtered through a celite pad and concentrated to give the title compound.

Workup

  1. filtrationThe solution was filtered through a celite pad
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-aac76817a0784ea096d2850178380bf0
Source dataset
uspto-grants-2001_10
Patent number
US06297239B1

Reaction notes

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