反应详情

4-(3-Methyl-3H-imidazole-4-carbonyl)-2-(naphthalen-2-yloxy)-benzonitrile (0.109 g, 0.308 mmol) was dissolved in anhydrous THF (5 mL) and a 3.0 M solution of MeMgBr (0.35 mL, 1.05 mmol) was added and stirred at RT. The reaction was quenched with NH4Cl after 1 h, concentrated, diluted with EtOAc, washed with satd. NaHCO3 solution, water, brine, dried (MgSO4) and concentrated to give the title compound. FT/ICR MS (M+1)=370.

1. customThe reaction was quenched with NH4Cl after 1 h
2. concentrationconcentrated
3. additiondiluted with EtOAc
4. washwashed with satd
5. dry with materialNaHCO3 solution, water, brine, dried (MgSO4)
6. concentrationconcentrated