反应详情

2-Fluoro-4-(3-methyl-3H-imidazole-4-carbonyl)-benzonitrile (0.603 g, 2.63 mmol) was dissolved in anhydrous THF (30 mL). A solution of 3.0M MeMgBr in diethyl ether (2.55 mL, 7.65 mmol) was added and stirred for 15 min. The reaction was quenched with NH4Cl solution, diluted with CH2Cl2 and saturated NaHCO3 solution and seperated. The aqueous layer was back extracted with CH2Cl2 (3×), the combined organic layers dried (MgSO4) and concentrated to give the title compound.

1. customThe reaction was quenched with NH4Cl solution
2. additiondiluted with CH2Cl2 and saturated NaHCO3 solution
3. customseperated
4. extractionThe aqueous layer was back extracted with CH2Cl2 (3×)
5. dry with materialthe combined organic layers dried (MgSO4)
6. concentrationconcentrated