反应详情

A mixture of 31.3 g (0.147 mol) of 6-nitro-4-oxo-1,4-dihydro-quinoline-3-carbonitrile and 160 mL of phosphorous oxychloride was refluxed for 5.5 h. The phosphorous oxychloride was removed in vacuo and the residue was poured over ice and neutralized with sodium bicarbonate. The product was collected, washed with water and dried in vacuo (50° C.). There was obtained 33.5 g of tan solid; solid: mass spectrum (electrospray, m/e): M+H 234.

1. temperaturewas refluxed for 5.5 h
2. customThe phosphorous oxychloride was removed in vacuo
3. additionthe residue was poured over ice and neutralized with sodium bicarbonate
4. customThe product was collected
5. washwashed with water
6. customdried in vacuo (50° C.)