3-Bromo-2-oxopropanoyl chloride → Propan-2-yl 3-bromo-2-oxopropanoate
Reaction equation
[Br:1][CH2:2][C:3](=[O:7])[C:4](Cl)=[O:5]>C(O)(C)C>[Br:1][CH2:2][C:3](=[O:7])[C:4]([O:7][CH:3]([CH3:4])[CH3:2])=[O:5]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 20 °C
Procedure
To iso-propanol was added 3-bromopyruvic chloride (5 g) at −5° C. dropwise and the solution was stirred overnight at 20° C. Evaporation of solvent gave iso-propyl 3-bromopyruvate (3.5 g), which was used in the next step without further purification.
Workup
- customEvaporation of solvent
Sources & evidence
- ORD record
- ord-30e92d70c0fe437cbd6454cf7b54316a
- Source dataset
- uspto-grants-2013_09
- Patent number
- US08524704B2
Reaction notes
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