HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Amino-4-(3-chloro-4-fluoro-phenylamino)-7-methoxy-quinoline-3-carbonitrile → 4-Bromo-but-2-enoic acid[4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-methoxy-quinolin-6-yl]-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Amino-4-(3-chloro-4-fluoro-phenylamino)-7-methoxy-quinoline-3-carbonitrile | HCID 11142436 | — |
| Reactant | (E)-4-Bromo-2-butenoyl Chloride | HCID 11263885 | — |
| Product | 4-Bromo-but-2-enoic acid[4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-methoxy-quinolin-6-yl]-amide | HCID 54242075 | — |
Reaction Steps
By using the method of Example 15, 4-bromo crotonyl chloride and 6-amino-4-(3-chloro-4-fluoro-phenylamino)-7-methoxy-quinoline-3-carbonitrile was converted to the title compound which was obtained as a solid that could be purified with boiling methanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06297258B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-181b74c1bc33466abdb973e3ebd1dfda |
| Source note | uspto-grants-2001_10 |