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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 3792Generated: October 25, 2026

1-Bromo-3-chloropropane → 4-Chlorobenzyl-4-(3-chloropropyl)piperazine dihydrochloride

https://huagongshe.com/reaction/3792

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Bromo-3-chloropropaneHCID 8006—
ReactantPotassium HydroxideHCID 14797—
Reactant4-ChlorobenzylpiperazineHCID 134826—
SolventDimethyl SulfoxideHCID 679—
Product4-Chlorobenzyl-4-(3-chloropropyl)piperazine dihydrochlorideHCID 2015318974%

Reaction Steps

Utilizing the procedure described in Example 1(a), 20.0 g of 1-(4-chlorobenzyl)piperazine, 100 ml of dimethyl sulfoxide, 15.0 g of potassium hydroxide and 15.0 of 1-bromo-3-chloropropane yielded 25.1 g (74% of theory) of 1-(4-chlorobenzyl)-4-(3-chloropropyl)piperazine dihydrochloride as a white crystalline solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04722926
Source datasetuspto-grants-1988_02
ORD IDord-2696e8dc20db40a1b56b86bc942054c8
Source noteuspto-grants-1988_02