Hydrochloric Acid → 5,6,7,8-Tetrahydro-1,8-naphthyridin-2-butyric acid hydrochloride

HRID 379218Notes

Reaction equation

HRID 379218 reaction equation

[NH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH2:11][CH2:12][CH2:13][C:14]([O:16]CC)=[O:15])[N:9]=2)[CH2:4][CH2:3][CH2:2]1.[ClH:19]>>[ClH:19].[NH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH2:11][CH2:12][CH2:13][C:14]([OH:16])=[O:15])[N:9]=2)[CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 313Hydrochloric Acid

HCID 22594332Ethyl 4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butanoate

Product 1

HCID 697760375,6,7,8-Tetrahydro-1,8-naphthyridin-2-butyric acid hydrochloride

Procedure

Ester 2-4 (1.8 g, 7.25 mmol) in 36 mL 6 N HCl was heated at 50° C. for 4 h, then concentrated, providing 2-5 as a yellow solid.

Workup

concentrationconcentrated

Sources & evidence

ORD record: ord-e8806b3451ba413fa85b6ec047dc0f4f
Source dataset: uspto-grants-2001_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06297249B1

Reaction notes

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