Hydrochloric Acid → HCID 53634676, compound

HRID 379230Notes

Reaction equation

HRID 379230 reaction equation
C([O:3][C:4](=[O:26])[CH2:5][C@@H:6]([C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([F:25])[CH:20]=1)[NH:7][CH2:8][C:9]1[CH:18]=[CH:17][C:16]2[CH2:15][CH2:14][CH2:13][NH:12][C:11]=2[N:10]=1)C.[OH-].[Na+].Cl>CCO>[F:25][C:21]1[CH:20]=[C:19]([C@@H:6]([NH:7][CH2:8][C:9]2[CH:18]=[CH:17][C:16]3[CH2:15][CH2:14][CH2:13][NH:12][C:11]=3[N:10]=2)[CH2:5][C:4]([OH:26])=[O:3])[CH:24]=[CH:23][CH:22]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 53933830HCID 53933830, compound

Product 1

HCID 53634676HCID 53634676, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of ester 9-2 (450 mg, 1.26 mmol) in EtOH (3 mL) was added 1N NaOH (1.39 ml, 1.39 mmol). After stirring for 1 h, the solvents were evaporated and the residue was dissolved in 1N HCl (1.39 ml, 1.39 mmol). The solution was concentrated and then azeotroped with CH3CN to give the acid 9-3 as a brown solid.

Workup

  1. customthe solvents were evaporated
  2. concentrationThe solution was concentrated
  3. customazeotroped with CH3CN

Sources & evidence

ORD record
ord-6aae96892bb54834b9e2be9bd8123e4d
Source dataset
uspto-grants-2001_10
Patent number
US06297249B1

Reaction notes

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