反应详情

A mixture of 11-4 (5.0 g, 24.8 mmol), 1-3, 2-amino-3-formylpyridine (3.6 g, 29.8 mmol) and 20% KOH (1 ml) in absolute ethanol (100 mL) was heated at reflux for 8 h. Following evaporative removal of the solvent, the residue was chromatographed (silica gel, 70:28:2 chloroform/ethyl acetate/methanol) to give 11-6 as a yellow oil.

1. temperaturewas heated
2. temperatureat reflux for 8 h
3. customremoval of the solvent
4. customthe residue was chromatographed (silica gel, 70:28:2 chloroform/ethyl acetate/methanol)