Ammonia → HCID 22678242, compound

HRID 379269Notes

Reaction equation

HRID 379269 reaction equation
C([O:3][C:4](=[O:19])[CH2:5][CH2:6][CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][N:12]=[C:11](S(C)(=O)=O)[N:10]=1)C.[NH3:20]>C1COCC1>[NH2:20][C:11]1[N:10]=[C:9]([CH2:8][CH2:7][CH2:6][CH2:5][C:4]([OH:3])=[O:19])[CH:14]=[CH:13][N:12]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 53820486HCID 53820486, compound

Product 1

HCID 22678242HCID 22678242, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 26-4 (0.19 g, 0.67 mmol) in THF (5 mL) was cooled to 0° and saturated with NH3 gas. The mixture was stirred at 0° for 4 h, then evaporated and the residue partitioned between EtOAc and sat. NaHCO3. The organic layer was dried filtered and concentrated to give the amino ester 26-5.

Workup

  1. customevaporated
  2. customthe residue partitioned between EtOAc and sat. NaHCO3
  3. customThe organic layer was dried
  4. filtrationfiltered
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-ae168b0ad75d4ebba59fdcf398474e04
Source dataset
uspto-grants-2001_10
Patent number
US06297249B1

Reaction notes

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