Hydrogen iodide → HCID 86754909, compound

HRID 379438Notes

Reaction equation

HRID 379438 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]([C:16]2[N:20]([CH2:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=3)[C:19]3[CH:28]=[CH:29][CH:30]=[CH:31][C:18]=3[N:17]=2)=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.[IH:32]>ClCCl>[IH:32].[N:23]1[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=1[CH2:21][N:20]1[C:19]2[CH:28]=[CH:29][CH:30]=[CH:31][C:18]=2[N:17]=[C:16]1[C:14]([CH:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)=[O:15]

Participants

4

Reactant 2

HCID 24841Hydrogen iodide2×HCID 21697612HCID 21697612, compound

Product 1

HCID 86754909HCID 86754909, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
0 °C

Procedure

Combine 1-(t-butoxycarbonyl)-4-(1-(pyrid-2-ylmethyl)-1H-benzimidazole-2-carbonyl)piperidine (1.96 g, 4.7 mmol) and dichloromethane (150 mL). Cool to 0° C. using an ice bath. Add hydriodic acid (gas) until the solution is saturated and stir. After 30 minutes, again add hydriodic acid (gas) until the solution is saturated. After 2 hours, evaporate in vacuo to give, after drying, the title compound: mp 165-167° C.

Workup

  1. waitAfter 2 hours
  2. customevaporate in vacuo
  3. customto give
  4. customafter drying

Sources & evidence

ORD record
ord-59f71644ba9f493790dc1b240f4ccdce
Source dataset
uspto-grants-2001_10
Patent number
US06297259B1

Reaction notes

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