4-(1-(4-fluorobenzyl)-1H-benzoimidazol-2-yl)-4-hydroxypiperidine → N-Methyl-N-(4-(4-(1-(4-fluorobenzyl)-1H-benzoimidazol-2-yl)-4-hydroxypiperidin-1-yl)-2-(4-methoxyphenyl)butyl)benzamide

HRID 379443Notes

Reaction equation

HRID 379443 reaction equation
[CH3:1][N:2]([CH2:11][CH:12]([C:19]1[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][CH:20]=1)[CH2:13][CH2:14]S(C)(=O)=O)[C:3](=[O:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[F:27][C:28]1[CH:50]=[CH:49][C:31]([CH2:32][N:33]2[C:37]3[CH:38]=[CH:39][CH:40]=[CH:41][C:36]=3[N:35]=[C:34]2[C:42]2([OH:48])[CH2:47][CH2:46][NH:45][CH2:44][CH2:43]2)=[CH:30][CH:29]=1>>[CH3:1][N:2]([CH2:11][CH:12]([C:19]1[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][CH:20]=1)[CH2:13][CH2:14][N:45]1[CH2:46][CH2:47][C:42]([C:34]2[N:33]([CH2:32][C:31]3[CH:49]=[CH:50][C:28]([F:27])=[CH:29][CH:30]=3)[C:37]3[CH:38]=[CH:39][CH:40]=[CH:41][C:36]=3[N:35]=2)([OH:48])[CH2:43][CH2:44]1)[C:3](=[O:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Participants

3

Reactant 2

HCID 155428854-(1-(4-fluorobenzyl)-1H-benzoimidazol-2-yl)-4-hydroxypiperidineHCID 18354479N-methyl-N-(2-(4-methoxyphenyl)-4-methanesulfonylbutyl)benzamide

Product 1

HCID 15870531N-Methyl-N-(4-(4-(1-(4-fluorobenzyl)-1H-benzoimidazol-2-yl)-4-hydroxypiperidin-1-yl)-2-(4-methoxyphenyl)butyl)benzamide

Procedure

Prepare by the method of Example 1.7 using N-methyl-N-(2-(4-methoxyphenyl)-4-methanesulfonylbutyl)benzamide and 4-(1-(4-fluorobenzyl)-1H-benzoimidazol-2-yl)-4-hydroxypiperidine to give the title compound.

Sources & evidence

ORD record
ord-aa7b9d92a1b54dd094672cedca202f92
Source dataset
uspto-grants-2001_10
Patent number
US06297259B1

Reaction notes

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