1-benzyl-2-(chloromethyl)-1H-imidazole hydrochloride → N-Methyl-N-(4-(4-(1-(imidazol-2-ylmethyl)-1H-benzimidazole-2-carbonyl)piperidin-1-yl)-2-phenylbutyl)benzamide

HRID 379473Notes

Reaction equation

HRID 379473 reaction equation
[CH3:1][N:2]([CH2:11][CH:12]([C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)[CH2:13][CH2:14][N:15]1[CH2:20][CH2:19][CH:18]([C:21]([C:23]2[NH:27][C:26]3[CH:28]=[CH:29][CH:30]=[CH:31][C:25]=3[N:24]=2)=[O:22])[CH2:17][CH2:16]1)[C:3](=[O:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.Cl.C([N:46]1[CH:50]=[CH:49][N:48]=[C:47]1[CH2:51]Cl)C1C=CC=CC=1>>[CH3:1][N:2]([CH2:11][CH:12]([C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)[CH2:13][CH2:14][N:15]1[CH2:16][CH2:17][CH:18]([C:21]([C:23]2[N:27]([CH2:51][C:47]3[NH:46][CH:50]=[CH:49][N:48]=3)[C:26]3[CH:28]=[CH:29][CH:30]=[CH:31][C:25]=3[N:24]=2)=[O:22])[CH2:19][CH2:20]1)[C:3](=[O:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Participants

3

Reactant 2

HCID 27792431-benzyl-2-(chloromethyl)-1H-imidazole hydrochlorideHCID 21697457N-methyl-N-(4-(4-(1H-benzimidazole-2-carbonyl)piperidin-1-yl)-2-phenylbutyl)benzamide

Product 1

HCID 21697366N-Methyl-N-(4-(4-(1-(imidazol-2-ylmethyl)-1H-benzimidazole-2-carbonyl)piperidin-1-yl)-2-phenylbutyl)benzamide

Procedure

Prepare by the method of Example 21.1 using N-methyl-N-(4-(4-(1H-benzimidazole-2-carbonyl)piperidin-1-yl)-2-phenylbutyl)benzamide and 1-benzyl-imidazol-2-ylmethylchloride hydrochloride to give the title compound.

Sources & evidence

ORD record
ord-6cbbaf4ea55e4019a81e5bdb97287024
Source dataset
uspto-grants-2001_10
Patent number
US06297259B1

Reaction notes

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