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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 379473Generated: October 25, 2026

1-benzyl-2-(chloromethyl)-1H-imidazole hydrochloride → N-Methyl-N-(4-(4-(1-(imidazol-2-ylmethyl)-1H-benzimidazole-2-carbonyl)piperidin-1-yl)-2-phenylbutyl)benzamide

https://huagongshe.com/reaction/379473

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-benzyl-2-(chloromethyl)-1H-imidazole hydrochlorideHCID 2779243—
ReactantN-methyl-N-(4-(4-(1H-benzimidazole-2-carbonyl)piperidin-1-yl)-2-phenylbutyl)benzamideHCID 21697457—
ProductN-Methyl-N-(4-(4-(1-(imidazol-2-ylmethyl)-1H-benzimidazole-2-carbonyl)piperidin-1-yl)-2-phenylbutyl)benzamideHCID 21697366—

Reaction Steps

Prepare by the method of Example 21.1 using N-methyl-N-(4-(4-(1H-benzimidazole-2-carbonyl)piperidin-1-yl)-2-phenylbutyl)benzamide and 1-benzyl-imidazol-2-ylmethylchloride hydrochloride to give the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06297259B1
Source datasetuspto-grants-2001_10
ORD IDord-6cbbaf4ea55e4019a81e5bdb97287024
Source noteuspto-grants-2001_10