HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 379492Generated: October 27, 2026
Hydrogen iodide → 4-(1-(2-(2,2,2-trifluoroethoxy)ethyl)-1H-benzimidazole-2-carbonyl)piperidine hydriodic acid salt
https://huagongshe.com/reaction/379492
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrogen iodide | HCID 24841 | — |
| Reactant | 1-(t-butoxycarbonyl)-4-(1-(2-(2,2,2-trifluoroethoxy)ethyl)-1H-benzimidazole-2-carbonyl)piperidine | HCID 21697352 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(1-(2-(2,2,2-trifluoroethoxy)ethyl)-1H-benzimidazole-2-carbonyl)piperidine hydriodic acid salt | HCID 86754911 | — |
Reaction Steps
Combine 1-(t-butoxycarbonyl)-4-(1-(2-(2,2,2-trifluoroethoxy)ethyl)-1H-benzimidazole-2-carbonyl)piperidine (5.0 mmol) and dichloromethane (150 mL). Cool to 0° C. using an ice bath. Add hydriodic acid (gas) until the solution is saturated and stir. After 30 minutes, again add hydriodic acid (gas) until the solution is saturated. After 2 hours, evaporate invacuo to give, after drying, the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06297259B1 |
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| Source dataset | uspto-grants-2001_10 |
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| ORD ID | ord-bab61d5808b24f8b9eef7993019637ff |
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| Source note | uspto-grants-2001_10 |
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