Hydrogen iodide → 4-(1-(2-(2,2,2-trifluoroethoxy)ethyl)-1H-benzimidazole-2-carbonyl)piperidine hydriodic acid salt

HRID 379492Notes

Reaction equation

C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]([C:16]2[N:20]([CH2:21][CH2:22][O:23][CH2:24][C:25]([F:28])([F:27])[F:26])[C:19]3[CH:29]=[CH:30][CH:31]=[CH:32][C:18]=3[N:17]=2)=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.[IH:33]>ClCCl>[IH:33].[F:28][C:25]([F:26])([F:27])[CH2:24][O:23][CH2:22][CH2:21][N:20]1[C:19]2[CH:29]=[CH:30][CH:31]=[CH:32][C:18]=2[N:17]=[C:16]1[C:14]([CH:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)=[O:15]

Participants

Conditions

Temperature: 0 °C

Procedure

Combine 1-(t-butoxycarbonyl)-4-(1-(2-(2,2,2-trifluoroethoxy)ethyl)-1H-benzimidazole-2-carbonyl)piperidine (5.0 mmol) and dichloromethane (150 mL). Cool to 0° C. using an ice bath. Add hydriodic acid (gas) until the solution is saturated and stir. After 30 minutes, again add hydriodic acid (gas) until the solution is saturated. After 2 hours, evaporate invacuo to give, after drying, the title compound.

Workup

waitAfter 2 hours
customevaporate invacuo
customto give
customafter drying

Sources & evidence

ORD record: ord-bab61d5808b24f8b9eef7993019637ff
Source dataset: uspto-grants-2001_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06297259B1

Reaction notes

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