6-Trifluoroacetylamino-quinoline → N-(1,2,3,4-tetrahydro-6-quinolyl)trifluoroacetamide

HRID 379673Notes

Reaction equation

HRID 379673 reaction equation
[F:1][C:2]([F:17])([F:16])[C:3]([NH:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[N:12]=[CH:11][CH:10]=[CH:9]2)=[O:4]>C(O)(=O)C.[Pt]=O>[F:17][C:2]([F:1])([F:16])[C:3]([NH:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[NH:12][CH2:11][CH2:10][CH2:9]2)=[O:4]

Participants

4

Reactant 1

HCID 103993716-Trifluoroacetylamino-quinoline

Product 1

HCID 10421907N-(1,2,3,4-tetrahydro-6-quinolyl)trifluoroacetamide

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 176Acetic AcidSolvent

Procedure

2,4 g (0.01 mol) of 6-trifluoroacetylamino-quinoline are dissolved in 20 ml glacial acetic acid and hydrogenated for I hour with 0.6 g platinum oxide at 3 bar. Then the catalyst is suction filtered and the solution is concentrated by evaporation. The residue is washed with a little sodium hydrogen carbonate solution and dried.

Workup

  1. filtrationfiltered
  2. concentrationthe solution is concentrated by evaporation
  3. washThe residue is washed with a little sodium hydrogen carbonate solution
  4. customdried

Sources & evidence

ORD record
ord-6bb49db1d3da4364b87f89882f92cf6a
Source dataset
uspto-grants-2001_10
Patent number
US06300342B1

Reaction notes

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