HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Sodium Hydroxide → 6-Amino1-[3-(4-cyano-phenyl)propionyl]-1,2,3,4-tetrahydro-quinoline
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Sodium Hydroxide | HCID 14798 | — |
| Edukt | 1,4-Dioxane | HCID 31275 | — |
| Edukt | 1-[3-(4-Cyano-phenyl)propionyl]-6-trifluoroacetylamino-1,2,3,4-tetrahydro-quinoline | HCID 15410771 | — |
| Lösungsmittel | Methanol | HCID 887 | — |
| Produkt | 6-Amino1-[3-(4-cyano-phenyl)propionyl]-1,2,3,4-tetrahydro-quinoline | HCID 15410772 | — |
Reaktionsschritte
16 g of 1-[3-(4cyano-phenyl)propionyl]-6-trifluoracetylamino-1,2,3,4-tetrahydro-quinoline are dissolved in 70 ml of methanol and 50 ml of dioxan and stirred with 200 ml of 1N sodium hydroxide solution for 2 hours at 40° C. Then the mixture is extracted with methylene chloride, the organic phase is dried over sodium sulphate and concentrated by evaporation.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06300342B1 |
| Quelldatensatz | uspto-grants-2001_10 |
| ORD ID | ord-23ccf613c5654aeea50baa6f6e33ac66 |
| Quellennotiz | uspto-grants-2001_10 |