HCID 18368279, compound → HCID 18368323, compound

HRID 379710Notes

Reaction equation

HRID 379710 reaction equation
[CH:1]([NH:4][CH2:5][CH2:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([N+:14]([O-])=O)=[CH:10][C:9]=1[O:17][CH3:18])([CH3:3])[CH3:2]>CO.[C].[Pd]>[CH:1]([NH:4][CH2:5][CH2:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([NH2:14])=[CH:10][C:9]=1[O:17][CH3:18])([CH3:3])[CH3:2]

Participants

4

Reactant 1

HCID 18368279HCID 18368279, compound

Product 1

HCID 18368323HCID 18368323, compoundYield 99.5%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

N-isopropyl-2-(2-methoxy-4-nitrophenoxy)ethylamine (9.29 g) solution in methanol (100 ml) was added with 10% palladium carbon catalyst and subjected to hydrogenation reaction at ambient pressure. After completion of hydrogenation reaction, catalyst was removed by filtration. Filtrate was concentrated under vacuum to obtain 4-[2-(isopropylamino)ethoxy]-3-methoxyaniline (8.15 g) as yellowish oily substance.

Workup

  1. customsubjected to hydrogenation reaction at ambient pressure
  2. customAfter completion of hydrogenation reaction, catalyst
  3. customwas removed by filtration
  4. concentrationFiltrate was concentrated under vacuum

Sources & evidence

ORD record
ord-1f6b31c8883847aaa2bec2bf041ebf8a
Source dataset
uspto-grants-2001_10
Patent number
US06300368B1

Reaction notes

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