HCID 53740103, compound → HCID 18368270, compound

HRID 379718Notes

Reaction equation

HRID 379718 reaction equation
[CH:1]([NH:4][CH2:5][CH2:6][O:7][C:8]1[C:13]([CH3:14])=[CH:12][C:11]([N+:15]([O-])=O)=[CH:10][C:9]=1[CH3:18])([CH3:3])[CH3:2]>CO.[C].[Pd]>[CH:1]([NH:4][CH2:5][CH2:6][O:7][C:8]1[C:13]([CH3:14])=[CH:12][C:11]([NH2:15])=[CH:10][C:9]=1[CH3:18])([CH3:3])[CH3:2]

Participants

4

Reactant 1

HCID 53740103HCID 53740103, compound

Product 1

HCID 18368270HCID 18368270, compoundYield 99%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

N-isopropyl-[2-(2,6-dimethyl-4-nitrophenoxy)]ethylamine (5.5 g) solution in methanol (70 ml) was subjected to hydrogenation reaction with 10% palladium carbon catalyst at ambient pressure. After completion of hydrogenation reaction, catalyst was removed by filtration. Filtrate was concentrated to obtain 4-[2-(isopropylamino) ethoxy]3,5-dimethylaniline (4.80 g) as pale brownish oil.

Workup

  1. customAfter completion of hydrogenation reaction, catalyst
  2. customwas removed by filtration
  3. concentrationFiltrate was concentrated

Sources & evidence

ORD record
ord-4f9d8cb2477e4a4d85cebc620356965e
Source dataset
uspto-grants-2001_10
Patent number
US06300368B1

Reaction notes

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