HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-1-(3-methylphenyl)ethan-1-one → 3-Amino-6-chloro-2-(3-methylbenzoyl)-1-(ethoxycarbonyl)indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-1-(3-methylphenyl)ethan-1-one | HCID 10036129 | — |
| Reactant | 4-Chloro-2-[(ethoxycarbonyl)amino]benzonitrile | HCID 18367888 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 3-Amino-6-chloro-2-(3-methylbenzoyl)-1-(ethoxycarbonyl)indole | HCID 18368043 | — |
Reaction Steps
The title compound was prepared according to the procedure described in step 2 of Example 1 from 4-chloro-2-(ethoxycarbonylamino)benzonitrile (Example 1, step 1) and 2-bromo-3′-methylacetophenone (R. Yveline, G. Gerard, and M. Geroges, Chem.Pharm.Bull., 1992, 40, 1170.). tlc: Rf=0.5 (25% ethyl acetate in hexanes)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06300363B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-c7cdabc5ada74c36a5184db7236b94a1 |
| Source note | uspto-grants-2001_10 |